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Research & development

Research, labelled for what it is.

A growing archive of our research, the system we use to label evidence, and interactive explainers for the ideas behind our work.

Evidence system

Three evidence labels. Every claim.

Every biological claim on this site carries one of these labels. This is what each one means.

Stage labels

Programmes and products carry a stage label, so nothing looks further along than it is.

In development
Being built; not available for use.
Not clinically validated
Not yet tested in a clinical study.
Active research
Being investigated; not a product.
Not a therapy
No treatment is offered.
Today
Exists and works in the prototype.
Future
Planned, not yet built.
Concept
An idea at the earliest stage.

Archive

Every output has a status.

From preprints and unpublished studies to formally published research, each item is labelled so you know what you're looking at.

  • PreprintIn preparation

    Müller glia regeneration

    Our first major research output, on the regenerative capacity of Müller glia. It will be listed as a preprint, not a peer-reviewed publication.

    Regenerative medicine
  • ThesisUnpublished

    The Man Who Lived Forever

    A research thesis by Abraham Nelson Dimzang. It may be added to the public archive if released.

    Regeneration & longevity

Interactive explainers

Ideas you can move.

Two of the ideas behind EDDS, as small models you can drag.

A. Baseline vs population

A value can be normal for the population and unusual for one person.

POPULATION RANGE · 150–450PERSONAL BASELINE · 280–320NEW RESULT300
Population
Within the population range
This person
Within this person's usual band

B. Signal vs noise

A result in isolation can be difficult to interpret. Repeated measurements can help distinguish ordinary variation from a sustained pattern. Add measurements to explore how a pattern develops over time.

EarlierLatest
Confidence in a trend
Emerging signal

Thresholds are for teaching only.

Areas of interest

Where our research is heading.

  • Müller glia and regenerative biology

  • Longitudinal biological interpretation

  • Computational health systems

  • Comparative regeneration and biological restoration

  • Future clinical and translational research

Research development pathway.

The intended progression of our research. Hypothesis and in silico work are current; the later stages are planned, not completed.

  1. HypothesisCurrent
  2. In silicoCurrent
  3. In vitroPlanned
  4. In vivoPlanned
  5. Clinical trialsPlanned

References

What we build on.

Our own research first, then the background literature, grouped by topic.

Dimzang research

See the archive above. Items are added here once they are publicly released.

Peer-reviewed literature

Published research behind our work, grouped by topic.

Müller glia and retinal regeneration

  1. Goldman, D. (2014). Müller glial cell reprogramming and retina regeneration. Nature Reviews Neuroscience, 15, 431–442. doi.org/10.1038/nrn3723
  2. Jorstad, N. L., et al. (2017). Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature, 548, 103–107. doi.org/10.1038/nature23283
  3. Karl, M. O., & Reh, T. A. (2010). Regenerative medicine for retinal diseases: activating endogenous repair mechanisms. Trends in Molecular Medicine, 16(4), 193–202. doi.org/10.1016/j.molmed.2010.02.003
  4. Wohl, S. G., & Reh, T. A. (2016). miR-124-9-9* potentiates Ascl1-induced reprogramming of cultured Müller glia. Glia, 64(5), 743–762. doi.org/10.1002/glia.22958
  5. Wohl, S. G., & Reh, T. A. (2016). The microRNA expression profile of mouse Müller glia in vivo and in vitro. Scientific Reports, 6, 35423. doi.org/10.1038/srep35423
  6. Zhou, et al. (2025). Advancements in Müller Glia Reprogramming: Pioneering Approaches for Retinal Neuron Regeneration. Neuroglia, 6(2), 20. doi.org/10.3390/neuroglia6020020

Axolotl and comparative regeneration

  1. Gerber, T., et al. (2018). Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science, 362(6413), eaaq0681. doi.org/10.1126/science.aaq0681
  2. Rivera-Gonzalez, G. C., & Morris, S. A. (2018). Tracing the Origins of Axolotl Limb Regeneration. Developmental Cell, 47(6), 675–677. doi.org/10.1016/j.devcel.2018.11.042
  3. Haas, B. J., & Whited, J. L. (2017). Advances in Decoding Axolotl Limb Regeneration. Trends in Genetics, 33(8), 553–565. doi.org/10.1016/j.tig.2017.05.006

Turritopsis dohrnii and reverse development

  1. Matsumoto, Y., Piraino, S., & Miglietta, M. P. (2019). Transcriptome Characterization of Reverse Development in Turritopsis dohrnii (Hydrozoa, Cnidaria). G3: Genes, Genomes, Genetics, 9(12), 4127–4138. doi.org/10.1534/g3.119.400487
  2. Matsumoto, Y., & Miglietta, M. P. (2021). Cellular Reprogramming and Immortality: Expression Profiling Reveals Putative Genes Involved in Turritopsis dohrnii’s Life Cycle Reversal. Genome Biology and Evolution, 13(7), evab136. doi.org/10.1093/gbe/evab136

Collaborate on the questions.

We work with researchers on regenerative biology and computational health.

Research collaboration